Drug discovery and development increasingly includes modeling aspects to identify drug targets, characterize drugs, evaluate drug candidates and guide the design of experimental trials.
Pharmacokinetic/pharmacodynamics (PK/PD) modeling has proved to help predict the effect and efficacy of drug dosing over time. However, Quantitative Systems Pharmacology (QSP) has emerged at the crossroads between traditional PK/PD and mechanistic systems biology modeling.
It combines a mechanistic model of disease pathophysiology, PK/PD of a therapeutic agent, and quantitative experimental data. The resulting model can be used to run simulations to understand how drugs modify cellular networks and how they are impacted by the (patho)physiology, the significant pathways, and the impact of drug parameters and biological variance on drug efficacy and safety
In this webinar we will demonstrate how to: